MKCCR Funds research to understand metastases
One of the challenges in cancer care is the development of metastases (the spread of cancer cells from their primary location to another region of the body). While we know biologically new mutations occur that drive these metastases and their growth, it is unclear whether there are different genetic mutations in the primary tumor as compared with metastases at different sites. In this latest project funded by Mezin-Koats Colon Cancer Research, Drs. Emil Lou and Andrew Nelson at Masonic Cancer Center at the University of Minnesota are attempting to perform extensive genomic analysis (including whole exome sequencing) of each of the tumors to determine potential differences between the metastatic tumors, to compare to normal tissue and to the original tumor.