Cormier-Scott Study looks at genes linked to colon cancer

With your help MKCCR has funded its third research project at the Masonic Cancer Center, University of Minnesota.  The Cormier-Scott lab is studying two genes—KCNQ1 and CFTR—that are specifically linked to poor prognosis colon cancer, even in the early stages.  These genes are expressed in the stem cell compartment, where colon cancer originates.  The Cormier-Scott lab is studying how the loss of these genes leads to cancer-causing changes in the stem cell compartment.  This knowledge will be used to develop new therapies to treat colon cancer by restoring expression of KCNQ1 and CFTR. 

MKCCR Funds research to understand metastases

One of the challenges in cancer care is the development of metastases (the spread of cancer cells from their primary location to another region of the body).  While we know biologically new mutations occur that drive these metastases and their growth, it is unclear whether there are different genetic mutations in the primary tumor as compared with metastases at different sites.  In this latest project funded by Mezin-Koats Colon Cancer Research, Drs. Emil Lou and Andrew Nelson at Masonic Cancer Center at the University of Minnesota are attempting to perform extensive genomic analysis (including whole exome sequencing) of each of the tumors to determine potential differences between the metastatic tumors, to compare to normal tissue and to the original tumor.

We are grateful to our generous contributors for making it possible for us to continue to fund these important projects