Dr. Emil Lou and team published in JBC

Emil Lou, MD, PhD, FACP and team recently completed a long-term project that came to completion utilizing an award from the Mezin-Koats Colon Cancer Research fund.

It took over five years and was a complex project. They discovered a novel form of mutation that drives a number of colorectal cancers. They found this one in a patient of Dr. Lou’s who had an especially aggressive colorectal cancer, and they collaborated with an expert group at the NIH to do the work.

The details can be found online at www.jbc.org. The title of the article is “RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling”.

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