Second Project Funded by MKCCR Underway
Emil Lou, MD and the team at his lab at the Masonic Cancer Center at University of Minnesota have continued to make progress in investigating intercellular communication in our colon cancer model. This research was made possible by a grant funded by Mezin-Koats Colon Cancer Research through generous donations from people like you.
The team has created a test to help examine transfer of important cell contents between cells and to determine with accuracy the mode of transport. They are now turning their attention to investigating the effects of this transfer on colon cancer cell growth, proliferation, and whether it makes the tumor cells more invasive.
Since last winter, they have also initiated a translational project examining a novel mutation in the protein N-Ras in human tumor tissue. N-Ras is one of the driving mutations responsible for initiation of colorectal cancer, but it has not been as well-studied as K-Ras. In collaboration with pathologist Andrew Nelson, MD, they identified a novel and previously unreported variant of the N-Ras.